Making an inference involves using reasoning to go beyond the explicit information provided in the text and to draw conclusions that are not directly stated. This process requires the reader to use their background knowledge and reasoning skills, making option B the most accurate statement. Option A is incorrect because inferences are not based solely on explicit information. Option C is misleading because, while inferences involve interpretation, they are not merely guesswork but are based on logical reasoning. Option D is incorrect because background knowledge plays a crucial role in the ability to make accurate inferences.